Pets: are you aware of the risks to human health?

There is no doubt America is a nation of animal lovers. In 2012, more than 62% of American households included at least one pet. But while most of us are aware of the numerous benefits of pet ownership, are you aware of its risks to human health?

Those of you who have a cat, dog, bird or any other animal in your household will likely consider that pet to be member of your family, and rightly so.

Though pets can offer a wide range of health benefits to humans, they can also pose a number of health risks.

Pets offer comfort and companionship, and we can't help but love them. In fact, when it comes to dogs, a recent study found the famous "puppy dog eyes" glare triggers a whopping 300% increase in owners' oxytocin levels - the "love hormone" involved in maternal bonding.

What is more, pets offer a number of benefits to human health. In December 2014, Medical News Today reported on a study that associated household pets with stronger social skills in children with autism. And in May 2013, a study published in the journal Circulation linked pet ownership to reduced risk of heart disease.

But while pets can benefit our health in a number of ways, they also have the potential to spread infection and cause human illness. In this Spotlight, we take a look at the some of the health risks associated with ownership of many of the nation's most-loved animals.

Campylobacteriosis

Most of us have heard of Campylobacter. The bacterium is one of the most common causes of diarrhea in the US, estimated to affect more than 1.3 million people annually.

As well as diarrhea, infection with Campylobacter - called campylobacteriosis - can cause cramping, abdominal pain and fever within 2-5 days of exposure to the bacteria.

While most cases are caused by exposure to contaminated food - particularly meat and eggs - and water, it can also be contracted through exposure to stool of an infected animal - including dogs and cats.

According to PetMD, around 49% of dogs and 45% of stray cats carry Campylobacter and shed it in their feces. It is most common in puppies and kittens younger than 6 months.

It should be noted that infection with Campylobacter is rarely life-threatening, though individuals with weak immune systems, young children and the elderly are most at risk.

Tapeworm, hookworm and roundworm

Dipylidium caninum is the most common tapeworm in both dogs and cats in the US. It is caused by ingestion of fleas that carry the tapeworm larvae. This can happen when the animal grooms itself.

D. caninum can be passed to humans, though the risk of infection is very low. It most commonly occurs in young children who accidentally swallow an infected flea.

According to the Centers for Disease Control and Prevention (CDC), flea control is the best way to reduce the risk of D. caninum infection in both pets and humans.

Hookworm infection in humans most commonly causes a skin condition called cutaneous larva migrans, in which the hookworm larvae penetrate the skin.

Ancylostoma brazilense, A. caninum, A. ceylanicum andUncinaria stenocephala are just some of the species of hookworm that can infect cats and dogs.

The hookworm parasite can be shed in the feces of animals, and humans can contract it by coming into contact with infected feces or contaminated soil and sand where such feces have been.

Hookworm infection in humans most commonly causes a skin condition called cutaneous larva migrans (CLM), in which the hookworm larvae penetrate the skin. This causes a red, itchy and sometimes painful rash.

In rare cases, specific strains of hookworm can infect the intestines of humans, causing abdominal pain and diarrhea.

Toxocariasis is an infection caused by the transmission of Toxocara - parasitic roundworms - from dogs and cats to humans. According to the CDC, almost 14% of Americans have Toxocara antibodies, indicating that millions of us have been exposed to the parasite.

In dogs and cats infected with Toxocara, eggs of the parasite are shed in their feces. Humans can contract the parasite by accidentally swallowing dirt that has been contaminated with these feces.

Though it appears human exposure to Toxocara is high, most people infected with it do not develop symptoms or become sick. In the rare cases people do become ill from toxocariasis, the condition may cause inflammation and vision loss in one eye (ocular toxocariasis), or abdominal pain, fever, fatigue and coughing due to damage to various organs (visceral toxocariasis).

Salmonellosis

Though not as cute and fluffy as kittens and puppies, reptiles - such as turtles, snakes and lizards - are owned by around 3% of households in the US.

There is no doubt reptiles are interesting creatures and can make brilliant pets, but they are also a carrier ofSalmonella - a bacteria responsible for salmonellosis. Humans can contract the bacteria simply through touching a reptile and ingesting the germs.

According to the CDC, more than 1 million people in the US become ill from Salmonella infection each year. Of these illnesses, more than 70,000 are caused by contact with reptiles.

Within 12-72 hours of being infected with Salmonella, people may experience diarrhea, fever and abdominal cramps that last around 4-7 days. While most people fully recover without treatment, others may need to be hospitalized.

Turtles are a main culprit of Salmonella infection in the US. The sale of turtles less than 4 inches was even banned by the US Food and Drug Administration (FDA) in 1975 because of their high disease risk - particularly among young children, the elderly and people with weak immune systems.

Rabies

Rabies is one of the most severe diseases that humans can contract from dogs and cats, as well as smaller animals such as ferrets. A recent study reported by MNT found the disease kills around 59,000 people worldwide every year.

Rabies is a disease that infects the central nervous system (CNS). Caused by a bite from an animal infected with rabies virus, the disease causes fever, headache and weakness, before progressing to more severe symptoms - including hallucinations, full or partial paralysis, insomnia, anxiety and difficulty swallowing. Death normally occurs within days of more serious symptoms appearing.

According to the CDC, domestic animals accounted for 8% of all rabid animals reported in 2010.

In the US, the most common way domestic animals can contract rabies is through a bite from infected wild animals, particularly foxes, raccoons, skunks and bats. Symptoms normally occur 1-3 days after infection and include excess salivation, paralysis and unusual shyness or aggression.

If an owner suspects their pet may have been bitten by a rabid animal, they must take them to a veterinarian for care immediately, even if they have been vaccinated against the virus. Any person who believes they may have been bitten by a rabid animal must seek immediate medical care.

Parrot fever

Despite its name, parrot fever does not only occur in parrots - all birds can be affected. However, human transmission of the disease most commonly involves parrots, parakeets, macaws, cockatiels and poultry - particularly turkeys and ducks.

Also known as psittacosis, parrot fever is a bacterial disease caused by a bacterium called Chlamydia psittacithat humans can contract through inhalation of birds' secretions, including urine and feces.

If a person becomes infected with C. psittaci, symptoms usually appear around 10 days after exposure. These may include fever, nausea and vomiting, diarrhea, fatigue, chest pain and shortness of breath.

In more severe cases, infection with C. psittaci can cause inflammation of the brain, liver and other internal organs. It can also reduce lung function and cause pneumonia.

It is important to note, however, that parrot fever in humans is very rare in the US. According to the CDC, fewer than 50 people a year are infected, and this has been the case since 1996.

Toxoplasmosis

Toxoplasmosis is a disease caused by a single-celled parasite - Toxoplasma gondii. It is most commonly contracted in humans through ingestion of undercooked or contaminated meat.

Cats shed T. gondii in their feces.

However, humans can also contract T. gondii by coming into contact with cat feces or any area or object contaminated with cat feces, as felines are carriers of it. T. gondii cannot be absorbed through skin, but infection can occur if the parasite is accidentally ingested.

It is estimated that more than 60 million people in the US are infected with T. gondii. However, very few people become ill from the infection as the human immune system is normally able to fight it.

If the infection does present symptoms, these may include swollen glands and muscle aches and pains. In very severe cases, T. gondii infection may cause damage to the brain and other organs, or eye damage.

Pregnant women, elderly individuals, young children and people with weakened immune systems are at highest risk of developing symptoms from T. gondii infection.

Cat-scratch disease

Although our cute little kitties very rarely mean to scratch us, it does happen. And while many of us think nothing of a small graze from a cat's claw, it has the potential to cause more damage than you may think.

Cat-scratch disease (CSD) is caused by a bacterium called Bartonella henselae, which around 40% of cats carry at some point in their lifetime, though most show no signs of illness.

B. henselae is most common in kittens under the age of 1 year, and since kittens are more likely to scratch during playtime, they are most likely to spread the bacterium to humans.

An early sign of CSD can be an infection at the site of the scratch around 3-14 days after it occurred, characterized by swelling, pain and tenderness. Headache, fever, loss of appetite and fatigue may also present, and in very rare cases, CSD can affect the brain, heart and other organs.

Children under the age of 5 years and individuals with weakened immune systems are most likely to experience severe symptoms from CSD.

What can be done to prevent pet-related infections?

It is clear pets can harbor an abundance of germs that can be passed to humans, but there are a number of ways pet-related infections can be prevented:

• Wash your hands - hygiene is key for preventing the majority of pet-related infections. After coming into contact with pets, their saliva or feces, hands should be washed thoroughly with warm, soapy water. A scratch or bite from a pet should also be cleaned immediately
• Pick up and dispose of feces - quickly disposing of your pet's feces, particularly in areas where children may play - can prevent the spread of disease to humans and other animals
• Avoid scratches and bites - the best way to avoid infections from pet bites and scratches is to avert them in the first place. If you are scratched by a cat, dog or other animal, clean the wound immediately with warm, soapy water. A cat or dog bite may require medical attention due to the risk of rabies or other serious infection
• Get your pet vaccinated and routinely evaluated - visit a veterinarian regularly to ensure your pet is healthy and to prevent infectious diseases. Also, ensure your pet is up-to-date with the required vaccinations.

It is important to note that the likelihood of a person catching a disease from their pet is low, particularly if the correct precautions are taken. With this in mind, there is no reason why the millions of pet owners in the US can't enjoy the companionship and joy their animals provide.

Continue to Read more ...

Beauty in the beasties: how some of the world's creepiest critters may benefit your health

Though a well-known hymn tells us we should love "all creatures great and small," loving some of the smaller creatures on Earth - particularly the creepy-crawly kind - can prove a little challenging. So many of us have a fear of spiders, for example, that it sits in the top 10 list of phobias worldwide. But maybe this Spotlight will evoke a little warmth toward the beasts; we look at the surprising ways in which spiders and some other creepy critters may benefit human health.

Researchers have identified genes in houseflies that make them immune to the pathogens they carry - a finding that could open the door to treatments for human illnesses.

Mary Astell - a 17th century English philosopher - once said: "None of God's creatures absolutely consider'd are in their own nature contemptible; the meanest fly, the poorest insect has its use and vertue." And it seems this may be true in relation to the medical world.

Take the common housefly. They feed on decaying organic matter - such as garbage and feces - and as a result, carry over 100 potentially life-threatening pathogens that can be transmitted to humans. Based on this information, it is no wonder many of us take the opportunity to swat the little pests when they come into close range.

But you may be surprised to learn that the common housefly could actually help scientists learn more about human illnesses. In a study published in the journal Genome Biology in October 2014, Dr. Jeff Scott and colleagues from Cornell University in Ithaca, NY, revealed how they sequenced the genome of the housefly using DNA from six female flies.

Comparing the DNA of the housefly with that of the fruit fly - which shares almost 60% of human genes - the team identified genes that make houseflies immune to the pathogens they carry, potentially bringing us closer to new treatments for human illnesses.

"The housefly genome provides a rich resource for enabling work on innovative methods of insect control, for understanding the mechanisms of insecticide resistance, genetic adaptation to high pathogen loads, host parasitoid interactions, and for exploring the basic biology of this important pest," the authors explained.

And this discovery is only the tip of the iceberg; there are many more equally as unpleasant critters that may offer benefits for human health.

Spiders: relieving pain and repairing nerve damage

Many of you are likely to be cringing at the sight of the word "spider." Millions of us hate the eight-legged monstrosities, running away at the speed of light when one randomly appears from under the sofa. But whatever your thoughts about these arachnids, there is no doubt they are amazing creatures.

There are believed to be at least 40,000 species of spiders worldwide, residing on every continent except Antarctica.

Though all spiders have the ability to bite, only around a dozen can cause harm to humans with their toxic venom. Black Widows, Brown Recluse spiders and Hobo spiders are some of the venomous spiders found in the US. A bite from one of these can cause symptoms such as fever, itching or rash, nausea and vomiting, high blood pressure and breathing difficulties. Only very rarely can a spider bite lead to death.

Researchers have identified compounds in spider venom that could help treat chronic pain.

But while spider venom can cause human harm, it may also aid human health. Earlier this month, Medical News Todayreported on a study conducted by researchers from The University of Queensland in Australia, who claimed to have identified compounds in spider venom that could help treat chronic pain in humans.

From screening the venoms of 205 species of spider, they discovered that 40% of venoms contained at least one compound that has the ability to block a pathway involved in chronic pain in humans, called Nav1.7. One particular compound that showed promise - called Hd1a - was identified in a species of spider calledHaplopelma doriae - a member of the tarantula family.

Study leader Prof. Glenn King believes the findings may lead to more effective treatments for the millions of people worldwide who suffer from chronic pain. "Untapping this natural source of new medicines brings a distinct hope of accelerating the development of a new class of painkillers that can help people who suffer from chronic pain that cannot be treated with current treatment options," he adds.

And it is not only spiders' venom that could aid progress in human medicine. Spider silk - the protein fiber that the creatures use to make their webs - may be useful for treating nerve damage in humans, according to a 2011 study by researchers from Hannover Medical School in Germany.

Spider silk is an extremely durable fiber, with one study claiming it is five times stronger than steel. The Hannover researchers believe its high durability makes spider silk a promising candidate for reconstructive nerve surgery, with the technique already proving successful in animal models.

Bees: helping to fight antibiotic resistance and treat HIV

Compared with spiders, we tend to have a higher tolerance for bees. Though they seem incapable of finding their way back out of an open window they just flew through - making us do a lot of curtain-flapping and arm-waving - they are responsible for producing one of the nation's most-loved foods: honey.

But according to scientists, these insects are capable of so much more. In 2013, MNT reported on a study published in Antiviral Therapy, in which researchers revealed how a toxin found in bee venom - melittin - has the potential to destroy human immunodeficiency virus (HIV).

The investigators, from the Washington University School of Medicine, explained that melittin is able to make holes in the protective, double-layered membrane that surrounds the HIV virus. Delivering high levels of the toxin to the virus via nanoparticles could be an effective way to kill it.

Study author Dr. Joshua L. Hood believes these findings could lead to the creation of a vaginal gel to halt HIV transmission. "Our hope is that in places where HIV is running rampant, people could use this gel as a preventive measure to stop the initial infection," he explained.

A more recent study published in September 2014 claims bees may also be useful for creating a new class of antibiotics. Researchers from the Lund University in Sweden discovered lactic acid bacteria in fresh honey found in the stomachs of bees that has antimicrobial properties.

The team found that the bacteria is effective against a number of drug-resistant pathogens responsible for potentially life-threatening infections, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus(VRE).

At a time when existing antibiotics are increasingly failing to work against such infections, the researchers say their findings suggest a viable alternative.

Scorpions: helping to treat heart problems

Like spiders, scorpions are creepy but fascinating. There are around 90 species of scorpions living in the US, most likely to be found in rocky and sandy areas.

While a scorpion's venom can cause heart problems, researchers have found it could also treat them.

All scorpions are venomous, though only 25-30 species possess a venom that is toxic enough to cause severe illness in humans.

A person who is unlucky enough to be stung by one of these more deadly species may experience difficulty breathing, muscle spasms, high blood pressure, a rise or reduction in heart rate and irregular heartbeat. But while their venom can cause heart problems, you may be surprised to learn that it could also treat them.

A 2011 study by researchers from the University of Wisconsin-Madison School of Medicine and Public Health found that compounds in the venom of the African Emperor scorpion, or Pandinus imperator, may be effective for the treatment of heart failure.

The researchers found that the compounds, called calcins, activate the release of calcium in human heart cells, allowing better heart muscle contraction - something that is limited in patients with heart failure.

Another study published in 2010 identified a compound in the venom of the Central American bark scorpion - a species commonly kept as a pet - that could stop heart bypasses from failing.

The study researchers - from the University of Leeds in the UK - explain that the compound, called margatoxin, could prevent neointimal hyperplasia following heart bypass surgery - a common complication that causes blood vessel blockage. Margatoxin works by blocking a potassium ion channel called Kv1.3, which is involved in neointimal hyperplasia.

"These results look promising, but we won't know if this approach will benefit patients undergoing bypass surgery until more research is undertaken in patients to establish its long-term efficacy and safety," commented Prof. Peter Weissberg, medical director at the British Heart Foundation, adding:

"This is a good example of a substance that is dangerous in its natural form - a scorpion sting, having potential medicinal benefits if used appropriately."

Frogs: aiding the fight against cancer

Of all the creatures featured in this Spotlight, frogs are probably one of the least feared, but they are certainly one of the most interesting. They have the ability to jump more than 20 times their body length, and some species - such as the Budgett's frog - have camouflage capabilities.

There are more than 6,000 species of frogs worldwide, of which 90 reside in the US. While many species of frog are venomous, very few cause harm to humans. In fact, some species of frog could aid humans in the fight against cancer.

In 2011 a study by researchers from Queen's University Belfast in Northern Ireland that revealed thediscovery of two proteins in the skin of the Waxy Monkey Frog and the Giant Firebellied Toad that can disrupt angiogenesis, or new blood vessel growth.

The researchers explain that cancer tumors develop their own blood supply, fueling themselves with oxygen and nutrients to help them grow. A protein that can switch off blood vessel growth means tumors would be unable to fuel themselves, meaning they would stop growing. "Stopping the blood vessels from growing will make the tumor less likely to spread and may eventually kill it. This has the potential to transform cancer from a terminal illness into a chronic condition," says study author Prof. Chris Shaw.

On the other hand, Prof. Shaw says such a protein could be used to activate blood vessel growth, which could treat a number of conditions in which rapid blood vessel repair is required, such as blood vessel damage following stroke.

Reptiles: helping to manage and treat diabetes

Some of you may not have heard of the Gila monster. Found in southwestern US and northwestern Mexico, it is the only venomous lizard in the US, and one of only a few venomous lizards worldwide. Rest easy, though; a bite from this beast is not fatal to healthy adults. But its saliva could be a lifesaver.

In 2007, a study by researchers from the University of North Carolina at Chapel Hill School of Medicine revealed how exenatide - a synthetic form of a compound found in the saliva of the Gila monster, called exendin-4 - may help people with diabetes control their condition and lose weight.

A synthetic form of a compound found in the saliva of the Gila monster - called exendin-4 - may help people with diabetes control their condition and lose weight.

The compound works by causing the pancreas to produce more insulin when blood sugar is too high. In the study, 46% of patients who were given exenatide in combination with diabetes drug metformin had good control of their blood sugar, compared with only 13% of control participants.

"The Gila monster only eats three or four times a year, and a compound produced in its salivary glands called exendin-4 may help them digest these meals very slowly over time. That is an advantageous quality when translated into controlling diabetes," commented Dr. Michael Trautmann of pharmaceutical company Eli Lilly - who helped develop the drug.

The Gila monster is not the only reptile that could help treat diabetes. A 2012 study published in Nature Communications found toxins in snake venom that could be beneficial for the condition, and they could even help treat high blood pressure and cancer.

The team analyzed gene sequences from the Burmese python and garter snake to reach their findings. They found that - although the venoms of these snakes can be harmful to humans - the toxins in them can be changed into harmless molecules that could make effective drugs.

"The venom gland of snakes appears to be a melting pot for evolving new functions for molecules, some of which are retained in venom for killing prey, while others go on to serve new functions in other tissues in the body," said lead author Dr. Nicholas Casewell, from the Liverpool School of Tropical Medicine in the UK.

It seems that what Mary Astell said is not far from the truth; even "the meanest fly" or "the poorest insect" has its uses.

Continue to Read more ...

Beauty in the beasties: how some of the world's creepiest critters may benefit your health

Though a well-known hymn tells us we should love "all creatures great and small," loving some of the smaller creatures on Earth - particularly the creepy-crawly kind - can prove a little challenging. So many of us have a fear of spiders, for example, that it sits in the top 10 list of phobias worldwide. But maybe this Spotlight will evoke a little warmth toward the beasts; we look at the surprising ways in which spiders and some other creepy critters may benefit human health.

Mary Astell - a 17th century English philosopher - once said: "None of God's creatures absolutely consider'd are in their own nature contemptible; the meanest fly, the poorest insect has its use and vertue." And it seems this may be true in relation to the medical world.

Take the common housefly. They feed on decaying organic matter - such as garbage and feces - and as a result, carry over 100 potentially life-threatening pathogens that can be transmitted to humans. Based on this information, it is no wonder many of us take the opportunity to swat the little pests when they come into close range.

But you may be surprised to learn that the common housefly could actually help scientists learn more about human illnesses. In a study published in the journal Genome Biology in October 2014, Dr. Jeff Scott and colleagues from Cornell University in Ithaca, NY, revealed how they sequenced the genome of the housefly using DNA from six female flies.

Comparing the DNA of the housefly with that of the fruit fly - which shares almost 60% of human genes - the team identified genes that make houseflies immune to the pathogens they carry, potentially bringing us closer to new treatments for human illnesses.

"The housefly genome provides a rich resource for enabling work on innovative methods of insect control, for understanding the mechanisms of insecticide resistance, genetic adaptation to high pathogen loads, host parasitoid interactions, and for exploring the basic biology of this important pest," the authors explained.

And this discovery is only the tip of the iceberg; there are many more equally as unpleasant critters that may offer benefits for human health.

Spiders: relieving pain and repairing nerve damage

Many of you are likely to be cringing at the sight of the word "spider." Millions of us hate the eight-legged monstrosities, running away at the speed of light when one randomly appears from under the sofa. But whatever your thoughts about these arachnids, there is no doubt they are amazing creatures.

There are believed to be at least 40,000 species of spiders worldwide, residing on every continent except Antarctica.

Though all spiders have the ability to bite, only around a dozen can cause harm to humans with their toxic venom. Black Widows, Brown Recluse spiders and Hobo spiders are some of the venomous spiders found in the US. A bite from one of these can cause symptoms such as fever, itching or rash, nausea and vomiting, high blood pressure and breathing difficulties. Only very rarely can a spider bite lead to death.

Researchers have identified compounds in spider venom that could help treat chronic pain.

But while spider venom can cause human harm, it may also aid human health. Earlier this month, Medical News Today reported on a study conducted by researchers from The University of Queensland in Australia, who claimed to have identified compounds in spider venom that could help treat chronic pain in humans.

From screening the venoms of 205 species of spider, they discovered that 40% of venoms contained at least one compound that has the ability to block a pathway involved in chronic pain in humans, called Nav1.7. One particular compound that showed promise - called Hd1a - was identified in a species of spider calledHaplopelma doriae - a member of the tarantula family.

Study leader Prof. Glenn King believes the findings may lead to more effective treatments for the millions of people worldwide who suffer from chronic pain. "Untapping this natural source of new medicines brings a distinct hope of accelerating the development of a new class of painkillers that can help people who suffer from chronic pain that cannot be treated with current treatment options," he adds.

And it is not only spiders' venom that could aid progress in human medicine. Spider silk - the protein fiber that the creatures use to make their webs - may be useful for treating nerve damage in humans, according to a 2011 study by researchers from Hannover Medical School in Germany.

Spider silk is an extremely durable fiber, with one study claiming it is five times stronger than steel. The Hannover researchers believe its high durability makes spider silk a promising candidate for reconstructive nerve surgery, with the technique already proving successful in animal models.

Bees: helping to fight antibiotic resistance and treat HIV

Compared with spiders, we tend to have a higher tolerance for bees. Though they seem incapable of finding their way back out of an open window they just flew through - making us do a lot of curtain-flapping and arm-waving - they are responsible for producing one of the nation's most-loved foods: honey.

But according to scientists, these insects are capable of so much more. In 2013, MNT reported on a study published in Antiviral Therapy, in which researchers revealed how a toxin found in bee venom - melittin - has the potential to destroy human immunodeficiency virus (HIV).

The investigators, from the Washington University School of Medicine, explained that melittin is able to make holes in the protective, double-layered membrane that surrounds the HIV virus. Delivering high levels of the toxin to the virus via nanoparticles could be an effective way to kill it.

Study author Dr. Joshua L. Hood believes these findings could lead to the creation of a vaginal gel to halt HIV transmission. "Our hope is that in places where HIV is running rampant, people could use this gel as a preventive measure to stop the initial infection," he explained.

A more recent study published in September 2014 claims bees may also be useful for creating a new class of antibiotics. Researchers from the Lund University in Sweden discovered lactic acid bacteria in fresh honey found in the stomachs of bees that has antimicrobial properties.

The team found that the bacteria is effective against a number of drug-resistant pathogens responsible for potentially life-threatening infections, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).

At a time when existing antibiotics are increasingly failing to work against such infections, the researchers say their findings suggest a viable alternative.

Scorpions: helping to treat heart problems

Like spiders, scorpions are creepy but fascinating. There are around 90 species of scorpions living in the US, most likely to be found in rocky and sandy areas.

While a scorpion's venom can cause heart problems, researchers have found it could also treat them.

All scorpions are venomous, though only 25-30 species possess a venom that is toxic enough to cause severe illness in humans.

A person who is unlucky enough to be stung by one of these more deadly species may experience difficulty breathing, muscle spasms, high blood pressure, a rise or reduction in heart rate and irregular heartbeat. But while their venom can cause heart problems, you may be surprised to learn that it could also treat them.

A 2011 study by researchers from the University of Wisconsin-Madison School of Medicine and Public Health found that compounds in the venom of the African Emperor scorpion, or Pandinus imperator, may be effective for the treatment of heart failure.

The researchers found that the compounds, called calcins, activate the release of calcium in human heart cells, allowing better heart muscle contraction - something that is limited in patients with heart failure.

Another study published in 2010 identified a compound in the venom of the Central American bark scorpion - a species commonly kept as a pet - that could stop heart bypasses from failing.

The study researchers - from the University of Leeds in the UK - explain that the compound, called margatoxin, could prevent neointimal hyperplasia following heart bypass surgery - a common complication that causes blood vessel blockage. Margatoxin works by blocking a potassium ion channel called Kv1.3, which is involved in neointimal hyperplasia.

"These results look promising, but we won't know if this approach will benefit patients undergoing bypass surgery until more research is undertaken in patients to establish its long-term efficacy and safety," commented Prof. Peter Weissberg, medical director at the British Heart Foundation, adding:

"This is a good example of a substance that is dangerous in its natural form - a scorpion sting, having potential medicinal benefits if used appropriately."

Frogs: aiding the fight against cancer

Of all the creatures featured in this Spotlight, frogs are probably one of the least feared, but they are certainly one of the most interesting. They have the ability to jump more than 20 times their body length, and some species - such as the Budgett's frog - have camouflage capabilities.

There are more than 6,000 species of frogs worldwide, of which 90 reside in the US. While many species of frog are venomous, very few cause harm to humans. In fact, some species of frog could aid humans in the fight against cancer.

In 2011, MNT reported on a study by researchers from Queen's University Belfast in Northern Ireland that revealed thediscovery of two proteins in the skin of the Waxy Monkey Frog and the Giant Firebellied Toad that can disrupt angiogenesis, or new blood vessel growth.

The researchers explain that cancer tumors develop their own blood supply, fueling themselves with oxygen and nutrients to help them grow. A protein that can switch off blood vessel growth means tumors would be unable to fuel themselves, meaning they would stop growing. "Stopping the blood vessels from growing will make the tumor less likely to spread and may eventually kill it. This has the potential to transform cancer from a terminal illness into a chronic condition," says study author Prof. Chris Shaw.

On the other hand, Prof. Shaw says such a protein could be used to activate blood vessel growth, which could treat a number of conditions in which rapid blood vessel repair is required, such as blood vessel damage following stroke.

Reptiles: helping to manage and treat diabetes

Some of you may not have heard of the Gila monster. Found in southwestern US and northwestern Mexico, it is the only venomous lizard in the US, and one of only a few venomous lizards worldwide. Rest easy, though; a bite from this beast is not fatal to healthy adults. But its saliva could be a lifesaver.

In 2007, a study by researchers from the University of North Carolina at Chapel Hill School of Medicine revealed how exenatide - a synthetic form of a compound found in the saliva of the Gila monster, called exendin -4 - may help people with diabetes control their condition and lose weight.

A synthetic form of a compound found in the saliva of the Gila monster - called exendin-4 - may help people with diabetes control their condition and lose weight.

The compound works by causing the pancreas to produce more insulin when blood sugar is too high. In the study, 46% of patients who were given exenatide in combination with diabetes drug metformin had good control of their blood sugar, compared with only 13% of control participants.

"The Gila monster only eats three or four times a year, and a compound produced in its salivary glands called exendin-4 may help them digest these meals very slowly over time. That is an advantageous quality when translated into controlling diabetes," commented Dr. Michael Trautmann of pharmaceutical company Eli Lilly - who helped develop the drug.

The Gila monster is not the only reptile that could help treat diabetes. A 2012 study published in Nature Communications found toxins in snake venom that could be beneficial for the condition, and they could even help treat high blood pressure and cancer.

The team analyzed gene sequences from the Burmese python and garter snake to reach their findings. They found that - although the venoms of these snakes can be harmful to humans - the toxins in them can be changed into harmless molecules that could make effective drugs.

"The venom gland of snakes appears to be a melting pot for evolving new functions for molecules, some of which are retained in venom for killing prey, while others go on to serve new functions in other tissues in the body," said lead author Dr. Nicholas Casewell, from the Liverpool School of Tropical Medicine in the UK.

It seems that what Mary Astell said is not far from the truth; even "the meanest fly" or "the poorest insect" has its uses.

Written by Honor Whiteman

Continue to Read more ...