Showing posts with label Urology / Nephrology. Show all posts
Showing posts with label Urology / Nephrology. Show all posts

Monday, July 13, 2015

Using garlic to combat antimicrobial resistant urinary tract infections

Garlic extract may be an effective weapon against multi-drug resistant strains of pathogenic bacteria associated with urinary tract infections (UTI), according to a recent study.

Garlic extract may be an effective weapon against multi-drug resistant strains of pathogenic bacteria associated with urinary tract infections (UTI), according to a recent study published in the Pertanika Journal of Tropical Agricultural Science.
Conducted by researchers at the Birla Institute of Technology and Sciences in India, the study found that "even crude extracts of [garlic] showed good activity against multidrug resistant strains where antibiotic therapy had limited or no effect. This provides hope for developing alternative drugs which may be of help in fighting the menace of growing antibacterial resistance," the team states.
Urinary tract infection is the second most common infectious disease encountered in community practice. Worldwide, about 150 million people are diagnosed each year with UTI, at a total treatment cost in the billions of dollars. Although UTI is usually treated with antibiotics, "emerging antimicrobial resistance compels us to look back into traditional medicines or herbal products, which may provide appropriate/acceptable alternative solutions," the authors argue.
Garlic (Allium sativum) has been traditionally used for the treatment of diseases since ancient times. A wide range of microorganisms -- including bacteria, fungi, protozoa and viruses -- are known to be sensitive to garlic preparations. Allicin and other sulphur compounds are thought to be the major antimicrobial factors in garlic.
In this study, the team found that 56% of 166 bacteria strains isolated from the urine of people with UTI showed a high degree of resistance to antibiotics. However, about 82% of the antibiotic resistant bacteria were susceptible to a crude aqueous extract of Allium sativum. According to the researchers, "ours is the first study to report the antibacterial activity of aqueous garlic extract against multidrug resistant bacterial isolates from infected urine samples leading to UTI."
"To conclude, there is evidence that garlic has potential in the treatment of UTI and maybe other microbial infections," says the team. "However, it is necessary to determine the bioavailability, side effects and pharmacokinetic properties in more detail."

Story Source:
The above post is reprinted from materials provided by Universiti Putra Malaysia (UPM).
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Thursday, June 4, 2015

Prostate Cancer: Causes, Symptoms and Treatments

Prostate cancer is a disease which only affects men. Cancer begins to grow in the prostate - a gland in the male reproductive system.
The word "prostate" comes from Medieval Latin prostate and Medieval French prostate. The ancient Greek word prostates means "one standing in front", from proistanai meaning "set before". The prostate is so called because of its position - it is at the base of the bladder.
Contents of this article:
  1. What is the prostate?
  2. Prostate cancer
  3. Classification of prostate cancer
  4. Signs and symptoms of prostate cancer
  5. Causes of prostate cancer
  6. Prostate cancer treatments
  7. Possible complications
Fast facts on prostate cancer
Here are some key points about prostate cancer. More detail and supporting information is in the main article.
  • After non-melanoma skin cancer, prostate cancer is the most common cancer among men in the US.
  • Prostate cancer is one of the leading causes of cancer death among men of all races and Hispanic origin populations.
  • In the US around 209,292 men are diagnosed with prostate cancer per year.
  • Around 27,970 men die from prostate cancer in the US each year.
  • According to the American Cancer Society about 1 man in 7 will be diagnosed with prostate cancer during his lifetime.
  • Prostate cancer mainly occurs in older men - about 6 cases in 10 are diagnosed in men 65 years or older.
  • Almost all prostate cancers are adenocarcinomas - cancers that begin in cells that make and release mucus and other fluids.
  • Prostate cancer often has no early symptoms.
  • Advanced prostate cancer can cause men to urinate more often or have a weaker flow of urine.
  • Most men diagnosed with prostate cancer do not die from it. More than 2.9 million men in the US diagnosed with prostate cancer at some point are still alive today.

What is the prostate?

The prostate is an exocrine gland of the male reproductive system, and exists directly under the bladder, in front of the rectum. An exocrine gland is one whose secretions end up outside the body e.g. prostate gland and sweat glands. It is approximately the size of a walnut.
male urinary system diagram
Diagram of the location of the prostate gland and nearby organs
The urethra - a tube that goes from the bladder to the end of the penis and carries urine and semen out of the body - goes through the prostate.
There are thousands of tiny glands in the prostate - they all produce a fluid that forms part of the semen. This fluid also protects and nourishes the sperm. When a male has an orgasm the seminal-vesicles secrete a milky liquid in which the semen travels. The liquid is produced in the prostate gland, while the sperm is kept and produced in the testicles. When a male climaxes (has an orgasm) contractions force the prostate to secrete this fluid into the urethra and leave the body through the penis.
Urine control
As the urethra goes through the prostate: the prostate gland is also involved in urine control (continence) with the use of prostate muscle fibers. These muscle fibers in the prostate contract and release, controlling the flow of urine flowing through the urethra.
The Prostate Produces Prostate-specific antigen (PSA)
The epithelial cells in the prostate gland produce a protein called PSA (prostate-specific antigen). The PSA helps keep the semen in its liquid state. Some of the PSA escapes into the bloodstream. We can measure a man's PSA levels by checking his blood. If a man's levels of PSA are high, it might be an indication of either prostate cancer or some kind of prostate condition.
It is a myth to think that a high blood-PSA level is harmful to you - it is not. High blood PSA levels are however an indication that something may be wrong in the prostate.
Male hormones affect the growth of the prostate, and also how much PSA the prostate produces. Medications aimed at altering male hormone levels may affect PSA blood levels. If male hormones are low during a male's growth and during his adulthood, his prostate gland will not grow to full size.
In some older men the prostate may continue to grow, especially the part that is around the urethra. This can make it more difficult for the man to pass urine as the growing prostate gland may be causing the urethra to collapse. When the prostate gland becomes too big in this way, the condition is called Benign Prostatic Hyperplasia (BPH). BPH is not cancer, but must be treated.

Prostate cancer

In the vast majority of cases, the prostate cancer starts in the gland cells - this is called adenocarcinoma. In this article, prostate cancer refers just to adenocarcinoma.
Prostate cancer is mostly a very slow progressing disease. In fact, many men die of old age, without ever knowing they had prostate cancer - it is only when an autopsy is done that doctors know it was there. Several studies have indicated that perhaps about 80% of all men in their eighties had prostate cancer when they died, but nobody knew, not even the doctor.
Experts say that prostate cancer starts with tiny alterations in the shape and size of the prostate gland cells - Prostatic intraepithelial neoplasia (PIN).
Doctors say that nearly 50% of all 50-year-old men have PIN. The cells are still in place - they do not seem to have moved elsewhere - but the changes can be seen under a microscope. Cancer cells would have moved into other parts of the prostate. Doctors describe these prostate gland cell changes as low-grade or high-grade; high grade is abnormal while low-grade is more-or-less normal.
Any patient who was found to have high-grade PIN after a prostate biopsy is at a significantly greater risk of having cancer cells in his prostate. Because of this, doctors will monitor him carefully and possibly carry out another biopsy later on.

Classification of prostate cancer

It is important to know the stage of the cancer, or how far it has spread. Knowing the cancer stage helps the doctor define prognosis - it also helps when selecting which therapies to use. The most common system today for determining this is the TNM (Tumor/Nodes/Metastases). This involves defining the size of the tumor, how many lymph nodes are involved, and whether there are any other metastases.
When defining with the TNM system, it is crucial to distinguish between cancers that are still restricted just to the prostate, and those that have spread elsewhere. Clinical T1 and T2 cancers are found only in the prostate, and nowhere else, while T3 and T4 have spread outside the prostate.
There are many ways to find out whether the cancer has spread. Computer tomography will check for spread inside the pelvis, bone scans will decide whether the cancer has spread to the bones, and endorectal coil magnetic resonance imaging will evaluate the prostatic capsule and the seminal vesicles.
The Gleason Score
A pathologist will look at the biopsy samples under a microscope. If cancer tissue is detected, the pathologist then grades the tumor. The Gleason System of grading goes from 2 to 10. The higher the number, the more abnormal the tissues are compared to normal prostate tissue.
Two numbers are added up to get a Gleason score:
  1. A number from 1 to 5 for the most common pattern observed under the microscope. This is the predominant grade and must be more than 51% of the sample.
  2. A number from 1 to 5 for the second most common pattern. This is the secondary grade and must make up more than 5% but less than 50% of the sample.
A Gleason score of 7 can have two meanings. Look at these two examples below:
  1. If the predominant grade is 3 and the secondary grade is 4, the Gleason score is 7.
  2. If the predominant grade is 4 and the secondary grade is 3, the Gleason score is also 7.
However, the first example, with a predominant score of 3, has a less aggressive cancer than the second example, with a predominant score of 4.
It is crucial that the tumor is graded properly, as this decides what treatments should be recommended.

Signs and symptoms of prostate cancer

During the early stages of prostate cancer there are usually no symptoms. Most men at this stage find out they have prostate cancer after a routine check up or blood test. When symptoms do exist, they are usually one or more of the following:
  • The patient urinates more often
  • The patient gets up at night more often to urinate
  • He may find it hard to start urinating
  • He may find it hard to keep urinating once he has started
  • There may be blood in the urine
  • Urination might be painful
  • Ejaculation may be painful (less common)
  • Achieving or maintaining an erection may be difficult (less common).
If the prostate cancer is advanced the following symptoms are also possible:

  • Bone pain, often in the spine (vertebrae), pelvis, or ribs
  • The proximal part of the femur can be painful
  • Leg weakness (if cancer has spread to the spine and compressed the spinal cord)
  • Urinary incontinence (if cancer has spread to the spine and compressed the spinal cord)
  • Fecal incontinence (if cancer has spread to the spine and compressed the spinal cord).

Causes of prostate cancer

Nobody is really sure of what the specific causes are. There are so many possible factors, including age, race, lifestyle, medications, and genetics, to name a few.

1) Age

Age is considered as the primary risk factor. The older a man is, the higher is his risk. Prostate cancer is rare among men under the age of 45, but much more common after the age of 50.

2) Genetics

Statistics indicate that genetics is definitely a factor in prostate cancer risk. It is more common among certain racial groups - in the USA prostate cancer is significantly more common and also more deadly among Afro-Americans than White-Americans. A man has a much higher risk of developing cancer if his identical twin has it. A man whose brother or father had/had prostate cancer runs twice the risk of developing it, compared to other men.
Studies indicate that the two faulty genes - BRCA 1 and BRCA 2 - which are important risk factors for breast cancer and ovarian cancer, have also been implicated in prostate cancer risk.
In a study scientists found seven new sites in the human genome that are linked to men's risk of developing prostate cancer.
Faulty BRCA2 gene linked to aggressive form of prostate cancer - researchers at the The Institute of Cancer Research, UK, reported in the Journal of Clinical Oncology (April 2013 issue) that men who have inherited the faulty BRCA2 gene are more likely to have the faster-spreading type of prostate cancer. The scientists say these men should receive treatment immediately after diagnosis with surgery or radiation therapy, rather than receive the "watchful waiting" approach.
Senior author Ros Eeles wrote that experts have already known that those with the faulty BRCA2 gene have a higher risk of developing prostate cancer. This is the first large study to demonstrate that the faulty gene is also linked to a faster spread of the disease and poorer survival.
This new discovery will make some health authorities around the world rethink their policies and procedures. In the United Kingdom, the National Health Service offers the same prostate cancer treatment for both carriers and non-carriers of the faulty BRCA2 gene.
Prof. Eeles said "It must make sense to start offering affected men immediate surgery or radiotherapy, even for early-stage cases that would otherwise be classified as low-risk. We won't be able to tell for certain that earlier treatment can benefit men with inherited cancer genes until we've tested it in a clinical trial, but the hope is that our study will ultimately save lives by directing treatment at those who most need it."

3) Diet

fruits and vegetables
A review of diets indicated that the Mediterranean diet mayreduce a person's chances of developing prostate cancer.Another study indicates that soy, selenium and green tea, offer additional possibilities for disease prevention - however, a more recent study indicated that combination therapy of vitamin E, selenium and soy does not prevent the progression from high-grade prostatic intraepithelial neoplasia (HGPIN) to prostate cancer. A diet high in vegetable consumption was found in a study to be beneficial.
A US pilot study on men with low risk prostate cancer found that following an intensive healthy diet and lifestyle regime focusing on low meat and high vegetable and fruit intake, regular exercise, yoga stretching, meditation and support group participation, can alter the way that genes behave and change the progress of cancer, for instance by switching on tumor killers and turning down tumor promoters.
Other studies have indicated that lack of vitamin D, a diet high in red meat may raise a person's chances of developing prostate cancer.
A study published in the journal Clinical Cancer Research suggests vitamin D deficiency may predict aggressive prostate cancer.

4) Medication

Some studies say there might be a link between the daily use of anti-inflammatory medicines and prostate cancer risk. A study found that statins, which are used to lower cholesterol levels, may lower a person's risk of developing prostate cancer.

5) Obesity

A study found a clear link between obesity and raised prostate cancer risk, as well as a higher risk of metastasis and death among obese people who develop prostate cancer.

6) Sexually transmitted diseases (STDs)

Men who have had gonorrhea have a higher chance of developing prostate cancer, according to research from the University of Michigan Health System.

7) Agent Orange

Veterans exposed to Agent Orange have a 48% higher risk of prostate cancer recurrence following surgery than their unexposed peers, and when the disease comes back, it seems more aggressive, researchers say. Another study found that Vietnam War veterans who had been exposed to Agent Orange have significantly increased risks of prostate cancer and even greater risks of getting the most aggressive form of the disease as compared to those who were not exposed.

8) Enzyme PRSS3 linked to aggressive prostate cancer

Scientists from the Mayo Clinic, Florida, reported in Molecular Cancer Research that PRSS3, an enzyme, changes the environment of prostate cancer cells, making the cancer much more likely to metastasize.
Senior researcher, Evette Radisky, Ph.D., said "This molecule is a protease, which means it digests other molecules. Our data suggests PRSS3 activity changes the environment around prostate cancer cells - perhaps by freeing them from surrounding tissue - to promote malignancy and invasiveness. I don't think PRSS3 is the only factor involved in driving aggressive prostate cancer, but it may be significant for a certain subset of this cancer - the kind that is potentially lethal."
Recent developments on prostate cancer causes from MNT news
Chronic prostate inflammation tied to nearly double risk of prostate cancer - a study reported in the journal Cancer Epidemiology, Biomarkers & Prevention, finds that compared to men with no such signs, men with chronic inflammationin non-cancerous prostate tissue may have nearly double the risk of developing prostate cancer.
Vasectomy linked with aggressive prostate cancer risk - In the largest and most comprehensive study of its kind, researchers from Harvard School of Public Health in Boston, MA, find that vasectomy is associated with a small increased risk of prostate cancer, and a larger increased risk for advanced or lethal prostate cancer.
Prostate cancer: high cholesterol, triglyceride levels may raise risk of recurrence - Among men who have surgery for prostate cancer, those who have high total cholesterol and triglyceride levels - two types of fat found in blood - may be at increased risk of disease recurrence. This is according to a study published in the journal Cancer Epidemiology, Biomarkers & Prevention.
Western diet could be fatal for prostate cancer patients - A new study has suggested that following a Western diet - high in red and processed meats, refined grains and high-fat dairy products - could increase the risk of death for people with prostate cancer from both prostate cancer and all causes.

Prostate cancer treatments

The following treatments are separated into early stage and advanced stage prostate cancers.

Early stage prostate cancer

If the cancer is small and contained - localized - it is usually managed by one of the following treatments:
  • Watchful waiting - not immediate treatment is carried out. PSA blood levels are regularly monitored.
  • Radical prostatectomy - the prostate is surgically removed.
  • Brachytherapy - radioactive seeds are implanted into the prostate.
  • Conformal radiotherapy - the radiation beams are shaped so that the region where they overlap is as close to the same shape as the organ or region that requires treatment, thus minimizing healthy tissue exposure to radiation.
  • Intensity modulated radiotherapy - beams with variable intensity are used. An advanced form of conformal radiotherapy usually delivered by a computer-controlled linear accelerator.
    Treatment recommendations really depend on individual cases. In general, if there is a good prognosis and the cancer is in its early stages, all options can be considered. However, they all have their advantages and disadvantages. The patient should discuss available options thoroughly with his doctor.

More advanced prostate cancer

If the cancer is more aggressive, or advanced, the patient may require a combination of radiotherapy and hormone therapy. Radiotherapy requires treatment on an everyday basis for up to about eight weeks. Radical surgery is also an option - the prostate is removed. Traditional surgery requires a hospital stay of up to ten days, with a recovery time that can last up to three months. Robotic keyhole surgery has the advantage just a couple of days in hospital, followed by a much shorter recover period. However, even robotic keyhole surgery may not be ideal for very elderly patients.
In advanced prostate cancer hormone therapy is very effective in slowing down, and even stopping the growth of cancer cells. Even if the hormone therapy stops working after a while, there are still other options the patient will be able to discuss with his doctor, such as participating in clinical trials.
Radioactive injection helps advanced prostate cancer patients live longer - scientists at The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, UK, reported in NEJM (New England Journal of Medicine) that radium-233, a radiation injection, directly targets tumors in the bone delivering short range radiation, causing minimal damage to healthy tissue. Radium, like calcium, is absorbed by the bone.
Delivering estrogen through skin patches may be an easier and safer way to treat prostate cancer than the hormone therapies that are currently used, British researchers explained in Lancet Oncology (March 2013 issue).
In May 2013, the US FDA approved Xofigo (radium Ra 223 dichloride) for metastatic castration-resistant prostate cancer that has reached bones but not other organs. Enzalutamide is taken in combination with docetaxel, another cancer medication.
Richard Pazdur, M.D., from the FDA, said "Xofigo binds with minerals in the bone to deliver radiation directly to bone tumors, limiting the damage to the surrounding normal tissues. Xofigo is the second prostate cancer drug approved by the FDA in the past year that demonstrates an ability to extend the survival of men with metastatic prostate cancer."
Xtandi (enzalutamide) was approved by the FDA in August 2012 for patients with metastatic castration-resistant prostate cancer that has spread or recurred.
Continue to Read more ...

Wednesday, March 25, 2015

Satisfying thirst and the kidneys: the importance of drinking water

Many people may take drinking water for granted, but keeping hydrated can have a huge impact on overall health. Despite how crucial it is that people drink enough water, a significant amount of people may be failing to drink recommended levels of fluids each day.

Woman drinking water.
The Institute of Medicine recommend that men achieve a daily fluid intake of around 3 liters and that women take in 2.2 liters.
Around of 70% of the body is comprised of water, and around of 71% of the planet's surface is covered by water. Perhaps it is the ubiquitous nature of water that means that drinking enough of it each day is not at the top of many people's lists of healthy priorities?
One part of the body that relies on adequate water intake is the kidneys. The kidneys are organs that might not get as much attention as the heart or lungs, but they are responsible for many functions that help keep the body as healthy as possible.
But what happens to the kidneys when we do not drink enough water? And what can be done to improve our levels of hydration? On World Kidney Day, we take a look at the role of drinking enough water for two of the most important organs in the body.

Why do we need to drink water?

Water is needed by all the cells and organs in the body in order for them to function properly. It is also used to lubricate the joints, protect the spinal cord and other sensitive tissues, regulate body temperature and assist the passage of food through the intestines.
Although some of the water required by the body is obtained through foods with a high water content - soups, tomatoes, oranges - the majority is gained through drinking water and other beverages.
During normal everyday functioning, water is lost by the body, and this needs to be replaced. It is noticeable that we lose water through activities such as sweating and urination, but water is even lost when breathing.
Drinking water, be it from the tap or a bottle, is the best source of fluid for the body. Beverages such as milk and juices are also decent sources of water, but beverages containing alcohol and caffeine, such as soft drinks, coffee and beer, are less than ideal due to having diuretic properties, meaning that they cause the body to release water.
The recommended amount of water that should be drunk per day varies from person to person depending on factors such as how active they are and how much they sweat. There is no universally agreed upon threshold of water consumption that must be reached, but there is a general level of consensus as to what a healthy amount is.
According to the Institute of Medicine (IOM), an adequate intake for men is approximately 13 cups (3 liters) a day. For women, an adequate intake is around 9 cups (2.2 liters).
Many people may have heard the phrase, "Drink eight 8-ounce glasses of water a day," which works out at around 1.9 liters and is close to the IOM's recommendation for women. Drinking "8 by 8" is an easy-to-remember amount that can put people on the right track in terms of water consumption.
Water also helps dissolve minerals and nutrients so that they are more accessible to the body, as well as helping transport waste products out of the body. It is these two functions that make water so vital to the kidneys.

What do the kidneys do?

The kidneys are two small fist-sized organs that are shaped like beans. They are located in the middle of the back, on either side of the spine and situated just below the rib cage.
Despite their importance, the kidneys can sometimes receive less attention than other organs in the body. "The role of the kidneys is often underrated when we think about our health," state Kidney Health Australia.
Cross-section of the kidneys.
The role of the kidneys in keeping the body healthy may be underrated in relation to the heart and the lungs.
"In fact, the kidneys play an important role in the daily workings of our body. They are so important to health that nature gave us two kidneys to cover the possibility that one might be lost to an injury. They are so important that with no kidney function, death occurs within a few days."
A crucial function of the kidneys is to remove waste products and excess fluid from the body via urine. The kidneys also regulate the levels of salt, potassium and acid in the body and produce hormones that influence the performance of other organs.
When we eat and drink, nutrients and minerals enter the bloodstream in order to be transported around the body and used for energy, growth, maintenance or repair. The blood also passes through the kidneys where it is filtered, and any waste products and excess nutrients and water are removed and sent to the bladder for expulsion.
Every day, the kidneys filter around 200 quarts of fluid. Of these, approximately 2 quarts are removed from the body in the form of urine, and 198 are recovered by the bloodstream.
If the kidneys do not function properly through kidney disease, waste products and excess fluid can build up inside the body. Untreated, chronic kidney disease can lead to kidney failure, whereby the organs stop working, and either dialysis or kidney transplantation is required.
Water is important for the workings of the kidneys, not only for helping to initially dissolve the nutrients, but for ensuring that waste products, bacteria and proteins do not build up in the kidneys and the bladder. These can lead to dangerous infections and painful kidney stones.

How does not drinking enough affect the kidneys?

Urinary tract infections (UTIs) are the second most common type of infection in the body and account for around 8.1 million visits to health care providers in the US every year. If infections spread to the upper urinary tract, including the kidneys, permanent damage can be caused. Sudden kidney infections (acute) can be life-threatening, particularly if septicemia occurs.
Drinking plenty of water is one of the simplest ways to reduce the risk of developing a UTI and is also advised for people that have developed an infection.
The presence of kidney stones can complicate UTIs as they can compromise how the kidneys work. Complicated UTIs tend to require longer periods of antibiotics to treat them, typically lasting between 7 and 14 days.
The leading cause of kidney stones is a lack of water, and they are commonly reported in people that have been found not drinking the recommended daily amount of water. As well as complicating UTIs, research has suggested that kidney stones also increase the risk of chronic kidney disease developing.
In November 2014, the American College of Physicians issued new guidelines for people who have previously developed kidney stones, stating that increasing fluid intake to enable 2 liters of urination a day could decrease the risk of stone recurrence by at least half with no side effects.
Dehydration - using and losing more water than the body takes in - can also lead to an imbalance in the body's electrolytes. Electrolytes, such as potassium, phosphate and sodium, help carry electrical signals between cells. The levels of electrolytes in the body are kept stable by properly functioning kidneys.
When the kidneys are unable to maintain a balance in the levels of electrolytes, these electrical signals become mixed up, which can lead to seizures, involving involuntary muscle movements and loss of consciousness.
In severe cases, dehydration can also lead to kidney failure, a potentially life-threatening outcome. Possible complications of chronic kidney failure include anemia, damage to the central nervous system, heart failure and a compromised immune system.
There are a considerable number of health problems that can occur simply through not drinking enough water, and yet researchers have found that a significant number of Americans may be failing to obtain the recommended levels of fluid intake every day.

Does the US not drink enough water?

A study carried out by the Centers for Disease Control and Prevention (CDC) in 2013 analyzed data from the National Cancer Institute's 2007 Food Attitudes and Behaviors Survey, in order to assess the characteristics of people who have a low intake of drinking water.
Person filling a glass from the tap.
A recent study conducted by the CDC suggested that many people in the US may not be drinking enough water.
Out of a sample of 3,397 adults, the researchers found the following:
  • 7% of adults reported no daily consumption of drinking water
  • 36% of adults reported drinking 1-3 cups of drinking water a day
  • 35% of adults reported drinking 4-7 cups of drinking water a day
  • 22% of adults reported drinking 8 cups or more a day.
People were more likely to drink less than 4 cups of drinking water daily if they consumed 1 cup or less of fruits or vegetables a day. The study indicates that among this sample, a large number of people may well have not been drinking the suggested 8 cups of fluid a day.
Although the study only measured the intake of drinking water and fluid can be gained from other beverages, water is the ideal source of fluid due to it being readily available, calorie-free, caffeine-free and alcohol-free.
The fact that 7% of respondents reported drinking no water at all daily, and that respondents who drank low volumes of water were associated with low levels of fruit and vegetable consumption, would suggest there is a certain number of people who are risking their health by not getting enough fluid.
Even if the respondents reporting low levels of water intake were obtaining enough fluid, it is likely that they would be obtaining it from sources that could potentially compromise their health in other ways.
"The biologic requirement for water may be met with plain water or via foods and other beverages," write the study authors. "Results from previous epidemiologic studies indicate that water intake may be inversely related to volume of calorically sweetened beverages and other fluid intake."

Thirst-quenching tips

The CDC make a number of suggestions that could help people increase the amount of water they normally drink:
  • Carrying a water bottle with you means that fluid can be accessed when out and about, at work or running errands
  • This water can be frozen in freezer-safe water bottles to provide a supply of ice-cold water all day long, which can be more satisfying than other beverages in certain situations
  • Adding a wedge of lime or lemon to water can give it a different edge that may improve its taste without affecting its nutritional value.
Drinking enough should be an easily achievable health goal. "Under normal conditions, most people can drink enough fluids to meet their water needs," state the CDC. Although it is a relatively simple step to take, it can easily get overlooked as part of increasingly hectic lifestyles.
On National Kidney Day, it is worth remembering the risks that can come from not getting enough fluids, and to raise a glass - ideally filled with water - to those underrated organs that do so much for the health of the body.
Continue to Read more ...

Sunday, March 22, 2015

Satisfying thirst and the kidneys: the importance of drinking water

May people may take drinking water for granted, but keeping hydrated can have a huge impact on overall health. Despite how crucial it is that people drink enough water, a significant amount of people may be failing to drink recommended levels of fluids each day.

Woman drinking water.
The Institute of Medicine recommend that men achieve a daily fluid intake of around 3 liters and that women take in 2.2 liters.
Around of 70% of the body is comprised of water, and around of 71% of the planet's surface is covered by water. Perhaps it is the ubiquitous nature of water that means that drinking enough of it each day is not at the top of many people's lists of healthy priorities?
One part of the body that relies on adequate water intake is the kidneys. The kidneys are organs that might not get as much attention as the heart or lungs, but they are responsible for many functions that help keep the body as healthy as possible.
But what happens to the kidneys when we do not drink enough water? And what can be done to improve our levels of hydration? On World Kidney Day, we take a look at the role of drinking enough water for two of the most important organs in the body.

Why do we need to drink water?

Water is needed by all the cells and organs in the body in order for them to function properly. It is also used to lubricate the joints, protect the spinal cord and other sensitive tissues, regulate body temperature and assist the passage of food through the intestines.
Although some of the water required by the body is obtained through foods with a high water content - soups, tomatoes, oranges - the majority is gained through drinking water and other beverages.
During normal everyday functioning, water is lost by the body, and this needs to be replaced. It is noticeable that we lose water through activities such as sweating and urination, but water is even lost when breathing.
Drinking water, be it from the tap or a bottle, is the best source of fluid for the body. Beverages such as milk and juices are also decent sources of water, but beverages containing alcohol and caffeine, such as soft drinks, coffee and beer, are less than ideal due to having diuretic properties, meaning that they cause the body to release water.
The recommended amount of water that should be drunk per day varies from person to person depending on factors such as how active they are and how much they sweat. There is no universally agreed upon threshold of water consumption that must be reached, but there is a general level of consensus as to what a healthy amount is.
According to the Institute of Medicine (IOM), an adequate intake for men is approximately 13 cups (3 liters) a day. For women, an adequate intake is around 9 cups (2.2 liters).
Many people may have heard the phrase, "Drink eight 8-ounce glasses of water a day," which works out at around 1.9 liters and is close to the IOM's recommendation for women. Drinking "8 by 8" is an easy-to-remember amount that can put people on the right track in terms of water consumption.
Water also helps dissolve minerals and nutrients so that they are more accessible to the body, as well as helping transport waste products out of the body. It is these two functions that make water so vital to the kidneys.

What do the kidneys do?

The kidneys are two small fist-sized organs that are shaped like beans. They are located in the middle of the back, on either side of the spine and situated just below the rib cage.
Despite their importance, the kidneys can sometimes receive less attention than other organs in the body. "The role of the kidneys is often underrated when we think about our health," state Kidney Health Australia.
Cross-section of the kidneys.
The role of the kidneys in keeping the body healthy may be underrated in relation to the heart and the lungs.
"In fact, the kidneys play an important role in the daily workings of our body. They are so important to health that nature gave us two kidneys to cover the possibility that one might be lost to an injury. They are so important that with no kidney function, death occurs within a few days."
A crucial function of the kidneys is to remove waste products and excess fluid from the body via urine. The kidneys also regulate the levels of salt, potassium and acid in the body and produce hormones that influence the performance of other organs.
When we eat and drink, nutrients and minerals enter the bloodstream in order to be transported around the body and used for energy, growth, maintenance or repair. The blood also passes through the kidneys where it is filtered, and any waste products and excess nutrients and water are removed and sent to the bladder for expulsion.
Every day, the kidneys filter around 200 quarts of fluid. Of these, approximately 2 quarts are removed from the body in the form of urine, and 198 are recovered by the bloodstream.
If the kidneys do not function properly through kidney disease, waste products and excess fluid can build up inside the body. Untreated, chronic kidney disease can lead to kidney failure, whereby the organs stop working, and either dialysis or kidney transplantation is required.
Water is important for the workings of the kidneys, not only for helping to initially dissolve the nutrients, but for ensuring that waste products, bacteria and proteins do not build up in the kidneys and the bladder. These can lead to dangerous infections and painful kidney stones.

How does not drinking enough affect the kidneys?

Urinary tract infections (UTIs) are the second most common type of infection in the body and account for around 8.1 million visits to health care providers in the US every year. If infections spread to the upper urinary tract, including the kidneys, permanent damage can be caused. Sudden kidney infections (acute) can be life-threatening, particularly if septicemia occurs.
Drinking plenty of water is one of the simplest ways to reduce the risk of developing a UTI and is also advised for people that have developed an infection.
The presence of kidney stones can complicate UTIs as they can compromise how the kidneys work. Complicated UTIs tend to require longer periods of antibiotics to treat them, typically lasting between 7 and 14 days.
The leading cause of kidney stones is a lack of water, and they are commonly reported in people that have been found not drinking the recommended daily amount of water. As well as complicating UTIs, research has suggested that kidney stones also increase the risk of chronic kidney disease developing.
In November 2014, the American College of Physicians issued new guidelines for people who have previously developed kidney stones, stating that increasing fluid intake to enable 2 liters of urination a day could decrease the risk of stone recurrence by at least half with no side effects.
Dehydration - using and losing more water than the body takes in - can also lead to an imbalance in the body's electrolytes. Electrolytes, such as potassium, phosphate and sodium, help carry electrical signals between cells. The levels of electrolytes in the body are kept stable by properly functioning kidneys.
When the kidneys are unable to maintain a balance in the levels of electrolytes, these electrical signals become mixed up, which can lead to seizures, involving involuntary muscle movements and loss of consciousness.
In severe cases, dehydration can also lead to kidney failure, a potentially life-threatening outcome. Possible complications of chronic kidney failure include anemia, damage to the central nervous system, heart failure and a compromised immune system.
There are a considerable number of health problems that can occur simply through not drinking enough water, and yet researchers have found that a significant number of Americans may be failing to obtain the recommended levels of fluid intake every day.

Does the US not drink enough water?

A study carried out by the Centers for Disease Control and Prevention (CDC) in 2013 analyzed data from the National Cancer Institute's 2007 Food Attitudes and Behaviors Survey, in order to assess the characteristics of people who have a low intake of drinking water.
Person filling a glass from the tap.
A recent study conducted by the CDC suggested that many people in the US may not be drinking enough water.
Out of a sample of 3,397 adults, the researchers found the following:
  • 7% of adults reported no daily consumption of drinking water
  • 36% of adults reported drinking 1-3 cups of drinking water a day
  • 35% of adults reported drinking 4-7 cups of drinking water a day
  • 22% of adults reported drinking 8 cups or more a day.
People were more likely to drink less than 4 cups of drinking water daily if they consumed 1 cup or less of fruits or vegetables a day. The study indicates that among this sample, a large number of people may well have not been drinking the suggested 8 cups of fluid a day.
Although the study only measured the intake of drinking water and fluid can be gained from other beverages, water is the ideal source of fluid due to it being readily available, calorie-free, caffeine-free and alcohol-free.
The fact that 7% of respondents reported drinking no water at all daily, and that respondents who drank low volumes of water were associated with low levels of fruit and vegetable consumption, would suggest there is a certain number of people who are risking their health by not getting enough fluid.
Even if the respondents reporting low levels of water intake were obtaining enough fluid, it is likely that they would be obtaining it from sources that could potentially compromise their health in other ways.
"The biologic requirement for water may be met with plain water or via foods and other beverages," write the study authors. "Results from previous epidemiologic studies indicate that water intake may be inversely related to volume of calorically sweetened beverages and other fluid intake."

Thirst-quenching tips

The CDC make a number of suggestions that could help people increase the amount of water they normally drink:
  • Carrying a water bottle with you means that fluid can be accessed when out and about, at work or running errands
  • This water can be frozen in freezer-safe water bottles to provide a supply of ice-cold water all day long, which can be more satisfying than other beverages in certain situations
  • Adding a wedge of lime or lemon to water can give it a different edge that may improve its taste without affecting its nutritional value.
Drinking enough should be an easily achievable health goal. "Under normal conditions, most people can drink enough fluids to meet their water needs," state the CDC. Although it is a relatively simple step to take, it can easily get overlooked as part of increasingly hectic lifestyles.
On National Kidney Day, it is worth remembering the risks that can come from not getting enough fluids, and to raise a glass - ideally filled with water - to those underrated organs that do so much for the health of the body.
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